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Landscape of Pediatric Acute Myeloid Leukemia
St. Jude Cloud
Data Resource:  St. Jude Cloud
Point of Contact:  
Clay McLeod ; Jinghui Zhang,  
Project

About This Dataset
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific driver alterations, many of which are underrepresented in the current classification schemas. To comprehensively define the genomic landscape of pAML, we systematically categorized 887 pAML into 23 mutually distinct molecular categories, including new major entities such as UBTF or BCL11B, covering 91.4% of the cohort. These molecular categories were associated with unique expression profiles and mutational patterns. For instance, molecular categories characterized by specific HOXA or HOXB expression signatures showed distinct mutation patterns of RAS pathway genes, FLT3 or WT1, suggesting shared biological mechanisms. We show that molecular categories were strongly associated with clinical outcomes using two independent cohorts, leading to the establishment of a new prognostic framework for pAML based on these updated molecular categories and minimal residual disease. Together, this comprehensive diagnostic and prognostic framework forms the basis for future classification of pAML and treatment strategies.
Core Data Elements
Number of Cases
224
Case Sex
Female (95); Male (129)
Case Age At Diagnosis
0 to 4 years (60); 5 to 9 years (42); 10 to 14 years (53); 15 to 19 years (65); 20 to 24 years (4)
Case Race
Black or African American (6); Native Hawaiian or Other Pacific Islander (1); White (15); Not Reported (202)
Case Ethnicity
Not Hispanic or Latino (19); Not Reported (205)
Case Disease Diagnosis
Acute Myeloid Leukemia, BCL11B rearrangement (2); Acute Myeloid Leukemia, CBFA2T3-GLIS2 (7); Acute Myeloid Leukemia, CBFB-MYH11 (27); Acute Myeloid Leukemia, CEBPA alteration (10); Acute Myeloid Leukemia, DEK-NUP214 (6); Acute Myeloid Leukemia, ETS family rearrangement (2); Acute Myeloid Leukemia, GATA1 alteration (2); Acute Myeloid Leukemia, HOX rearrangement (1); Acute Myeloid Leukemia, KAT6A rearrangement (2); Acute Myeloid Leukemia, KMT2A partial tandem duplication (2); Acute Myeloid Leukemia, KMT2A rearrangement (61); Acute Myeloid Leukemia, MECOM rearrangement (2); Acute Myeloid Leukemia, NOS (15); Acute Myeloid Leukemia, NPM1 alteration (21); Acute Myeloid Leukemia, NUP98 rearrangement (18); Acute Myeloid Leukemia, PICALM-MLLT10 (2); Acute Myeloid Leukemia, RBM15-MKL1 (2); Acute Myeloid Leukemia, RUNX1-RUNX1T1 (32); Acute Myeloid Leukemia, UBTF tandem duplication (10)
Case Tumor Site
Blood (224)
Number of Samples
272
Sample Assay Method
RNA Sequencing (221); Whole Exome Sequencing (8); Whole Genome Sequencing (43)
Additional Data Elements
DATA REPOSITORY
Grant Information
P30CA021765
Cancer Center Support Grant (CCSG)
U54CA243124
Experimental and preclinical modeling of NUP98-rearranged acute leukemia
Published In
https://doi.org/10.1038/s41588-023-01640-3
SAMPLE TYPE
Diagnosis (227);  
Germline (39);  
Relapse (6);  
Charts
Male (129); Female (95)
129Male